Access the most advanced pathogen testing available

After years of research—utilizing technology developed at The George Washington University Computational Biology Institute and funded by the National Science Foundation—Aperiomics Xplore-Patho® test has now served clinicians in 18 countries worldwide, giving hope to thousands of patients.


Clinically Actionable. Scientifically Groundbreaking.

Delivering on the decades-old promise of genomic sequencing and scientific innovation, Xplore-Patho is more efficient and effective than any other test on the market.

We can now identify every pathogen known to modern science with 97% sensitivity and 99.99% specificity.

When standard testing is inconclusive, symptoms persist, leaving patients suffering. For your patients with chronic or mysterious infections, Xplore-Patho can be critical to finally developing the best treatment plan

Clinician Brochure Fact Sheet Testing Guide

How It Works


Set up a free clinician portal


Order collection kits to have on hand


Collect patient samples


Complete requisition form


Ship to Aperiomics at no cost


Receive and interpret report

The Aperiomics Difference

We use a technology called deep metagenomic sequencing to create a genetic fingerprint of every known microorganism in a given sample.

After we clean up the data we run the remaining sequences through Xplore-ID℠, our industry-leading metagenomic algorithm, and against Xplore-DB℠, one of the largest, most complete microbial databases.

Standards of Excellence

We partner with the same laboratories routinely used by clinicians and hospitals. These are CLIA-certified labs, vetted by the state and federal government for precision, accuracy, and validity as well as independent third-party performance verifications. We only work with the best because we have the highest standards for our own work, too.

We offer 11 different collection kits

Blood plasma, breast milk, cerebrospinal fluid, deep nasal swab, fecal, prostate secretion, sputum, tissue, urine, vaginal swab, and wound swab.

View Testing Guide

Efficient and Cost-effective

Since our test allows for the identification of all known microorganisms—unlike older methods, which only test for a few microbes at a time—our cost per microbe is far more affordable than any other method.


of older testing fails to identify the causes of infection


of the genomic fingerprint is examined in Aperiomics testing

Deep metagenomic sequencing allows Aperiomics to screen for

~ 40,000 microorganisms, 12,000 of which are known to cause human disease.

  • Who is Aperiomics?

    Aperiomics is the only company of its kind and scope in the world. It is revolutionizing the way that medical professionals around the world detect and diagnose infections. Supported by the National Science Foundation, Aperiomics identifies every known bacteria, virus, fungus, and parasite through deep shotgun metagenomic sequencing. We help doctors and their patients identify the causes of infections that other tests cannot identify, thus streamlining the path to a positive clinical outcome. Many patients that we have helped were sick for years with no understanding of why. Patients and their physicians often contact Aperiomics after hearing about our life-changing success stories. The complete genetic fingerprint of a sample is created and compared to Aperiomics’ Xplore- PATHO database – a comprehensive database of over 37,000 microorganisms, including the world’s largest collection of known pathogens. Aperiomics was named Life Science’s Innovator of the Year in 2016 and International Start Up of the Year in 2018.

  • What does Aperiomics test for?

    Aperiomics tests for all known bacteria, virus, parasites and fungi based on the sequenced genomes from thousands of scientists around the world.  This includes microbes that can cause intestinal issues, urinary tract infections, Lyme disease and many other issues.

  • How is the appropriate type of sample(s) for testing determined and what collection kits should be ordered?

    Physicians should be able to tell patients which kit or kits they’ll need to help identify the pathogens causing your illness.  While a single kit may be needed, in some instances patients may require additional kits (blood, swab, urine, fecal, tissue or semen) to capture the pathogens at the suspected source of the infection. 

    For most accurate results, we test from the closest source of infection(s), where you feel your symptoms. For example, if you have an upset stomach or diarrhea, we would have you do a fecal kit, or for urinary tract infections, we would suggest a urine kit, etc. If there are NO CLEAR SIGNS OF SYMPTOMS, we suggest a blood plasma kit.

  • Do the biologicial samples have to be refrigerated or frozen?

    No.  Our specialized collection kits contain a solution that renders samples non-infectious and keeps the genetic material that we need intact for up to 30 days at room temperature.  Combined with our supplied packing materials, it also makes it safe for shipping… so no need to worry.

  • Are there any medications, probiotics, or treatment to discontinue before testing?

    For us to get the best possible sample, it is typically recommended that all anti-infective treatments (antifungals, antiparasitics, antibiotics) be stopped 3 days prior to sample collection. This should be discussed with a healthcare provider. 

    Probiotics should be stopped 14 days prior. All anti-infective treatments and probiotics should be listed on the requisition form, so our infectious disease doctor is aware of this when interpreting your results during the post- results physician consultation.

  • How does Aperiomics testing differ from what other companies offer?

    Most labs test for just one or a handful of pathogens at a time. Others are only focuse on one aspect like bacteria.  Aperiomics tests for ALL known pathogens at once!  This is the most comprehensive testing available on the market and one of the best options for identifying chronic or cryptic infections.

  • How do I get the results?

    Results are sent to healthcare providers securely and directly. For international patients, results are sent to you or your physician on file (if applicable).

    If needed, one can schedule a consultation with our infectious disease doctor on staff to interpret and understand patient results.

  • What’s the difference between PCR and next-generation sequencing testing?

    PCR is a technology that makes many copies of a small portion of a microorganism’s genetic information.  It can be inexpensive and sensitive, but is extremely limited in how many microorganisms can be identified in a single test – typically less than a dozen in one test.  Further, because PCR creates many copies of small genetic pieces, it is heavily biased and cannot be used to assess abundance of microbial populations.


    In contrast, NGS  (shotgun metagenomic sequencing) creates a genetic fingerprint of everything in the sample.  It is a much more comprehensive approach, capable of identifying tens of thousands of microorganisms in one sample, only limited by the availability of sequence data.  Aperiomics’ approach to NGS reduces as much bias as possible and allows abundance of microbial populations to be assessed.

  • Why is next-generation sequencing(shotgun metagenomics) testing more accurate than culture-growing testing?

    Culture is a 100+ year old technology that is limited to identifying only what will grow in culture.  Given that many microorganisms will not grow in culture, this technology is dramatically limited in the number of microorganisms that can be identified.  Culture creates bias because just one bacterial cell can grow and render a sample positive for that bacteria, irrespective of if that bacteria is causing an active infection.  Additionally, culture does not allow for consistent, objective identification of microorganisms to the species level.

    Not all NGS techniques are the same though, there are multiple different forms. Some, used by our competitors only look at bacteria and have difficulty looking at the species and strain level. The type of NGS we use, called shotgun metagenomic sequencing, is one of the most powerful among NGS techniques able to do it all.

    Shotgun metagenomics is more specific than culture can be because it identifies the identity of microorganisms according to the genetic sequence and not simply appearance of growth in culture.

  • What’s the difference between 16S NGS and shotgun metagenomics sequencing NGS?

    16S NGS is similar to PCR in that it creates many copies of specific genetic information.  These copies are then compared to a database to identify the bacteria present in a given sample.  16S sequencing is good at identifying thousands of bacteria to the genus level, but is unable to identify virus, fungi, or parasites.  Deep shotgun metagenomics sequencing, on the other hand, is able to identify tens of thousands of microorganisms and differentiate species of bacteria, virus, parasites, and fungi.

  • How long does it take to get the test results?

    Upon receipt of the patient’s sample kit, it typically takes 2-3 weeks for a report to be generated and uploaded to the clinician portal.


    Once the report is generated and sent to the ordering clinician, the clinician can sign up for a complimentary consultation with one of our infectious disease experts on staff. Our on staff infectious disease expert will walk the ordering clinician through the report and provide them with insight, context, and understanding surrounding the report.


    When the ordering clinician wishes to schedule a complimentary consultation, they can do so on their clinician portal.

  • Do patients or customers need to be sick in order to have Aperiomics test them?

    No, patients or general customers do not need to be sick to be tested.  In some cases it may be desired to know one’s normal microbial population.  Aperiomics can perform a complete metagenomic microbiome assessment from any clinical sample. 

    Many patient’s have found it beneficial to know what their healthy body’s microbial state looks like to serve as a baseline for comparison in the event they do become ill in the future.

  • Why would there be a need to test multiple samples at one time?

    In some cases, if there is not a clear, single site of infection (or symptom), we will request that multiple samples be collected and tested.  In this case, we will request multiple sample to ensure the best possible results.

  • Is there anything to be careful of when shipping samples?

    When collected as instructed, samples are rendered non-infectious and stable at ambient temperatures for up to 30 days.  The supplied shipping materials will return the sample next-day, and thus no special concerns are needed when shipping samples back to Aperiomics.

    Your physician (for US patients only) and you will receive your results within 10-14 days after sample is returned to Aperiomics.

  • Do I have to be a doctor to order your testing services?

    Aperiomics typically requires a clinician be involved in the collection and ordering of our testing.  This allows for the proper documentation for potential insurance reimbursement, as well as allowing for proper interpretation of results for the patient.

    International patients do not need a supporting physician to order the test.

  • What does Aperiomics have planned in the future?

    Items that are in the pipeline or in development now include drug resistance identification, the ability to identify true unknowns, disease prediction and biosurveillance.

  • Will Aperiomics contact clinicians?

    Aperiomics will want to talk to clinicians for the first time account setups. This is a simple process and we will have someone to help them along the way.  An Aperiomics representative will call to notify the clinician’s office when the report is done, that way, you and your physician can sit down with the results and a treatment plan can be created.

    Only US patients require a supporting physician.

  • Which sample kit should I order?

    KITS OFFERED: blood plasma, fecal (feces), urine, tissue, swab, sputum (deep throat saliva and mucus), cerebrospinal fluid, prostate secretion, and breast milk.

    *swabs can also be used for environmental tests, such as your home, floors, outside surfaces, etc. 

    For most accurate results, we test from the closest source of infection(s), where you feel your symptoms. For example, if you have an upset stomach or diarrhea, we would have you do a fecal kit, or for urinary tract infections, we would suggest a urine kit, etc.

    US patients require a supporting physician in order to receive the test. Typically, your physician can identify which test kit you will need.


  • Do I need a supporting doctor to able to order this test?

    US patients require a supporting physician in order to get this test. We cannot send you a test until you have a doctor who is willing to support you by reviewing your results and creating a treatment plan post result review.

    If needed, your physician can schedule a consultation with our infectious disease doctor on staff.

  • Why do I need a physician in order to get this test?

    In the US, it is required to have a physician to support you in order to have this test.

    The physician will provide ICD-10 codes for potential insurance reimbursement as well as provide result analysis in order to diagnose and create a treatment plan to get you better.

  • What exactly does “parasite” mean?

    We at Aperiomics define parasites as the currently sequenced parasitic worm, amoeba, and archaea genomes. Outside of worms this does not include multicellular things like mites or insects. Mites and multicellular organisms are typically glaringly obvious through a simple microscope and do not require the cutting edge DNA sequencing Aperiomics provides to diagnose.

  • What sample kits do you offer?

    KITS OFFERED: blood plasma, fecal (feces), urine, tissue, swab, sputum (deep throat saliva and mucus), cerebrospinal fluid, prostate secretion, and breast milk.

    *swabs can also be used for environmental tests, such as your home, floors, outside surfaces, etc. 

  • Do you ship kits/ serve patients internationally?


    We serve patients in most major international areas, and do this often.


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